Stavudine, Oral

Type of medicine: nucleoside reverse transcriptase inhibitor; antiretroviral (anti-HIV)

Generic and brand names: stavudine, oral; Zerit; d4T

This medicine is taken by mouth to treat HIV infection.

Before taking this medicine, tell your health care provider if you have ever had:

• an allergic reaction to any medicine
• liver or kidney disease
• peripheral neuropathy.

Females of childbearing age: Tell your health care provider if you are pregnant or plan to become pregnant while taking this medicine. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine.

This medicine comes in capsule and liquid forms.

Take this medicine exactly as your health care provider prescribes. Do not take more of it or take it more often than directed. Do not stop taking this medicine or change your dosage unless directed to do so by your health care provider.

If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your health care provider.

This medicine is not a cure for HIV infection. You may continue to get other illnesses or infections. Treatment with this medicine may reduce the frequency of the illnesses. This medicine does not reduce the risk of infecting other people through sexual contact or blood contamination. There is no information about the effects of long-term treatments.

You will need to have lab tests regularly to see how this medicine affects you. Keep all appointments for these tests.

Lactic acidosis is a rare but serious problem that can occur with use of this medicine. Stop taking this medicine and contact your health care provider right away if you develop unexplained symptoms such as:

• feel very ill, cold, dizzy, or lightheaded
• have muscle pain, nausea, trouble breathing, or increasing drowsiness
• suddenly have a slow or irregular heartbeat.

Treatment with this medicine may cause a change in the location of fat in your body. Discuss this with your health care provider.

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your health care provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your health care provider right away. If you are unable to reach your health care provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives, itching, rash, tightness in your chest, swelling of your lips, tongue or throat, trouble breathing).

Serious (report these to your health care provider right away): Slow or irregular heartbeat; dark urine; diarrhea; fever; light-colored bowel movements; muscle or joint pain; severe nausea and tiredness; pale skin; seizures; severe muscle weakness; shortness of breath; stomach pain; seizures; severe dizziness; severe back or leg pain; swelling in ankles or feet; tingling, numbness, or pain in the hands or feet; unexplained cough or sore throat; unusual bruising or bleeding; vomiting; yellow skin or eyes.

Other: Headache, chills, abdominal pain, diarrhea, insomnia, anxiety, depression, nervousness, sweating, mild itching.

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your health care provider if you are taking:

• alcohol
• antiviral medicines such as amprenavir (Agenerase), nelfinavir (Viracept), ritonavir (Norvir), delavirdine (Rescriptor), ribavirin (Rebetol, Rebetron, Virazole), stavudine (Zerit), tenofovir (Viread), and zalcitabine (Hivid)
• medicines used to treat cancer such as cisplatin (Platinol), hydroxyurea (Hydrea), doxorubicin (Adriamycin, Rubex, Doxil), vinblastine (Velban, Alkaban-AQ), and vincristine (Oncovin, Vincasar)
• methadone (Dolophine)
• St. John's Wort.

Do not drink alcohol while you are taking this medicine. Discuss this with your health care provider.

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all health care providers who treat you about all the products you are taking.

Store the oral solution (liquid) in the refrigerator, but do not freeze. Shake the liquid well before pouring a dose. Store the capsules at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your health care provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.