Oxycodone/Ibuprofen, Oral

Type of medicine: narcotic analgesic (painkiller)

Generic and brand names: oxycodone and ibuprofen, oral; Combunox Tablets

This medicine is taken by mouth to help relieve pain. It contains both a narcotic pain reliever (oxycodone) and ibuprofen.

Before you take this medicine, tell your health care provider if you have ever had:

• an allergic reaction to any medicine
• Addison's disease
• asthma or other breathing problems
• blood disorders or bleeding problems
• heart disease
• high or low blood pressure
• kidney or liver disease
• pancreatitis
• problems with drug or alcohol abuse
• seizures
• thyroid problems
• trouble urinating
• ulcers.

Females of childbearing age: Talk with your health care provider if you are pregnant or plan to become pregnant. This medicine should not be used during the third trimester of pregnancy because it may harm the baby. Do not breast-feed while taking this medicine without your health care provider's approval.

Take this medicine exactly as your health care provider prescribes. Do not take more or take it for a longer period of time than prescribed because this medicine may be habit-forming. Usually you will take it for 10 days or less. Also, taking too much of this medicine may increase your risk of side effects. Do not take more than 4 tablets in a 24 hour period.

You may take this medicine with or without food. Taking it with meals may lessen the chance the drug will upset your stomach.

This medicine increases the effects of alcohol and other drugs that slow down your nervous system. Do not drink alcohol or take other medicines unless your health care provider approves.

This medicine may make you drowsy or dizzy. Do not drive or operate machinery unless you are fully alert.

You may feel dizzy or faint when you get up quickly after sitting or lying down. Getting up slowly may help.

This medicine is a controlled substance. It is illegal for you to give it to anyone else.

If you need emergency care, surgery, lab tests, or dental work, tell the health care provider or dentist you are taking this medicine.

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your health care provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your health care provider right away. If you cannot reach your health care provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your health care provider right away): Black tarry or bloody stool; swelling of your feet, ankles, legs, or other parts of your body; fever; yellowing of your skin or eyes; vision changes; trouble urinating; unusual bruising or bleeding; severe stomach cramps; bloody vomit.

Other: Headache, nausea, vomiting, diarrhea, constipation, drowsiness, dizziness, thirst, dry mouth, heartburn, sweating.

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your health care provider if you are taking:

• ACE inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil), and quinapril (Accupril)
• alcohol
• angiotensin II blockers such as candesartan (Atacand), losartan (Cozaar), and valsartan (Diovan)
• anticholinergic medicines such as benztropine (Cogentin), dicyclomine (Bentyl), atropine sulfate, belladonna, propantheline (Pro-Banthine), methscopolamine (Pamine), l-hyoscyamine (Levsin, Levsinex), amantadine (Symmetrel), procyclidine (Kemadrin), and trihexyphenidyl (Artane)
• antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), and clemastine fumarate (Tavist)
• antianxiety medicines such as alprazolam (Xanax), diazepam (Valium), and lorazepam (Ativan)
• aspirin
• cholestyramine (Questran, LoCHOLEST) and colestipol (Colestid)
• cyclosporine (Sandimmune, Neoral)
• digoxin (Lanoxin)
• diuretics such as furosemide (Lasix) and hydrochlorothiazide (Esidrix)
• herbal remedies such as cat's claw, dong quai, evening primrose, feverfew, garlic, ginger, ginkgo, green tea, ginseng, valerian, St. John's wort, kava, and gotu kola
• lithium (Lithonate, Lithobid, Lithotabs, Eskalith)
• MAO inhibitor antidepressants such as phenelzine (Nardil), tranylcypromine (Parnate), and isocarboxazid (Marplan) (Do not take this medicine and an MAO inhibitor within 14 days of each other.)
• methotrexate
• muscle relaxants such as tizanidine (Zanaflex), cyclobenzaprine (Flexeril), carisoprodol (Soma), methocarbamol (Robaxin), dantrolene (Dantrium), and baclofen (Lioresal)
• narcotics such as pentazocine (Talwin), morphine (MS Contin, Oramorph SR, Roxanol), meperidine (Demerol), oxycodone (Percocet, Tylox, OxyContin), hydrocodone with acetaminophen (Vicodin), fentanyl (Duragesic, Actiq), butorphanol (Stadol NS), nalbuphine (Nubain), codeine, hydrocodone (Vicodin, Lortab), and propoxyphene (Darvocet N-100)
• nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Motrin IB, Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve, Naprelan), ketoprofen (Orudis, Orudis KT, Oruvail), nabumetone (Relafen), indomethacin (Indocin), ketorolac (Toradol), sulindac (Clinoril), piroxicam (Feldene), diclofenac (Voltaren, Cataflam), and oxaprozin (Daypro)
• phenothiazines such as chlorpromazine (Thorazine), prochlorperazine (Compazine), mesoridazine (Serentil), perphenazine (Trilafon), promazine (Sparine), thioridazine (Mellaril), and trifluoperazine (Stelazine)
• phenytoin (Dilantin)
• sedatives such as phenobarbital, butabarbital (Butisol), amobarbital (Amytal), zolpidem (Ambien), triazolam (Halcion), and zaleplon (Sonata)
• tricyclic antidepressants such as amitriptyline, clomipramine (Anafranil), and nortriptyline (Aventyl, Pamelor)
• warfarin (Coumadin).

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all health care providers who treat you about all the products you are taking.

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your health care provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.